pentobarbital will lessen the extent or effect of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Strong CYP3A4 inducers may possibly lower midostaurin concentrations resulting in lessened efficacy.
pentobarbital will decrease the extent or impact of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will decrease the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. The efficacy of hormonal contraceptives may very well be reduced.
pentobarbital will lower the extent or result of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.
pentobarbital will reduce the level or impact of copyright topical by affecting hepatic enzyme CYP2B6 metabolism. Minimal/Significance Not known.
Minimal (1)pentobarbital will lower the level or result of paclitaxel protein bound by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
benzhydrocodone/acetaminophen and pentobarbital both of those increase sedation. Keep away from read more or Use Alternate Drug. Limit use to clients for whom alternate remedy selections are insufficient
pentobarbital will reduce the extent or result of dasatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the extent or outcome of eltrombopag by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep an eye on.
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Observe. Drugs that increase delta-aminolevulinic acid synthetase could reduce hemin effect.
Warning with use for the duration of surgical procedures or processes in small children younger than 3 yr or in pregnant Females all through their 3rd trimester
pentobarbital will lessen the level or influence of norgestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Average CYP3A4 inducers could lessen progestin concentration; take into account usage of extra barrier approaches
With therapeutic doses of TCAs, barbiturates improve metabolism and decrease blood concentrations of TCAs.
Monitor Carefully (two)pentobarbital will lower the extent or result of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. If coadministration with a CYP3A4 inducer is critical, take into consideration raising oliceridine dose until finally secure drug effects are attained; observe for signs of opioid withdrawal.